ABCG5 Polyclonal Antibody from Bioassay Technology Laboratory

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1: MDR/TAP: MRP: ALD: OABP: GCN20: White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver: colon: and intestine. This gene is tandemly arrayed on chromosome 2: in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis: and have been observed in patients with sitosterolemia